What is Endotoxin?

Endotoxin is a complexed lipopolysaccharide (LPS), a toxic substance found in the outer cell membrane of most gram-negative bacteria. The bacteria releases endotoxin into the culture environment while growing and upon cell death.

Studies have shown that endotoxin levels may possibly affect the growth or performance of some cultures in specific applications but does not affect all cells equally.

Industry standard for endotoxin in fetal bovine serum (FBS) is ≤ 10 EU/ml with the highest grade reporting at ≤ 1 EU/ml. Peak Serum provides low-endotoxin FBS but generally this is not necessary for many cell lines and applications. We are happy to offer a wide range of cost effective FBS products to help personalize your serum needs.

Back to Blog